Scientific Activity

Improvement of Measures to Ensure Biological Safety in Kazakhstan: Counteraction to Dangerous and Especially Dangerous Infections

Preparing for Initial/Periodic Inspection: Recommendations and Practical Steps for GMP Standards for Veterinary Medicinal Products. Practical guide

Directions of scientific activity of subsidiaries

JSC “Scientific Center for Anti-Infective Drugs”:

– development of new drugs with selective pharmacological action and biologically active substances, study of their physical and chemical properties and modeling of the structure of new substances and substances; study of the mechanisms of formation of bioactive substances and their stability;

– conducting scientific research at the intersection of related sciences (radiology, cytology, molecular biology), studying the mechanism of action and transport in a living organism of drugs labeled with radioactive isotopes;

– determination of the degree of humoral and cellular immune responses of animals and humans when exposed to medicinal substances in vivo and in vitro models;

– study of the antimicrobial efficacy of synthesized substances using CLSI and EUCAST methods, study of the mechanisms of action of drugs on bacterial cells, assessment of the potential mutagenic activity of new compounds within the framework of preclinical studies in accordance with the GLP standard;

– study of the mechanisms of formation of bacterial resistance to antibiotics and possible ways to overcome it, study of the mechanisms of genetically determined resistance of multiresistant strains that pose a threat to the biological safety of the Republic of Kazakhstan using next-generation sequencing, isolation, identification and determination of the sensitivity profile of clinical isolates isolated from healthcare facilities in Almaty, identification and characterization of pathogenicity and virulence factors;

– conducting studies of drug interactions (synergism, potentiation);

– scientific, methodological and analytical support of research based on international standards ISO, GLP and GMP, laboratory control of pilot production;

– development, research and implementation of methodological, methodological and technological foundations for the automation and intellectualization of complex modeling processes in biomedical research.

JSC “National Center for Biotechnology”:

– conducting molecular genetic studies: searching for genetic markers to predict and assess the risk of developing multifactorial diseases (oncological diseases, metabolic diseases, cerebrovascular diseases, etc.); pharmacogenetics; nutrigenetics; genomic studies; molecular genetic identification of various objects; development of PCR test systems for diagnosing infectious diseases in animals and humans; molecular genetic analysis of pathogens for the purpose of epidemiological monitoring; genogeographic studies of the gene pool; research in the field of paleogenetics; research in the field of forensic genetics; formation of a population genetic biobank of the Central Asian population;

– genetic engineering: molecular virology, study of viral replication mechanisms; creation of viral vectors for genetic modification of cells in vitro and ex vivo for gene therapy and CAR-T technology for the treatment of leukemia and lymphomas; production of recombinant antigens; fundamental research in the field of DNA repair of human bacterial pathogens ( Mycobacterium tuberculosis , Helicobacter pylori , Staphylococcus aureus ); functional characteristics of CRISPR/Cas systems for the development of affordable next-generation molecular diagnostics;

– proteomic studies: proteomic studies using mass spectrometry, systems biology (genome and proteome); search for new proteomic and epigenetic markers of oncological diseases and development of methods for their diagnosis; paleoproteomics;

– cellular and tissue engineering technologies: development of cellular and tissue engineering drugs for the treatment of wounds, articular cartilage defects and fractures; development of innovative methods and approaches to cellular therapy of autoimmune diseases using mesenchymal stem cells; development of “smart” and functionalized biomaterials, polymers for tissue engineering and regenerative medicine;

– research in the field of veterinary medicine: obtaining feed additives and probiotic preparations for use in agriculture;

– biotechnology and plant breeding: creation of new forms and varieties of plants; development of technologies for microclonal propagation of woody plants for landscaping; conservation and reproduction of endemic, rare, endangered and medicinal plant species using biotechnology methods; molecular genetic identification of plant varieties and forms, pathogens; creation of a gene bank and in vitro collection of rare and endangered plant species; molecular phytopathology; study and conservation of the biodiversity of plant genetic resources; development of technologies for obtaining plant stem cells for use as a source of biologically active substances;

– microbiology: isolation and study of microorganisms with biotechnological value; obtaining and studying enzymes, antigens, protein factors; targeted modification of enzymes, antigens, proteins; obtaining biotechnological products by microbial synthesis; isolation and replenishment of the collection of microorganisms with probiotic properties; isolation and replenishment of the collection of strains for the creation of biofertilizers, for bioremediation of anthropogenically disturbed soils of Kazakhstan; development of technology for fermentation, concentration, lyophilization of microorganisms;

– toxicology and pharmacology: bioscreening; toxicology; biomodeling; blood rheology pharmacology; transport systems; pharmacoeconomics;

– biological safety: prompt response to biological threats, including those caused by unknown pathogens, by means of metagenomic multisequencing and genetic analysis; implementation of reference functions in the field of sequencing and genomic analysis of pathogens of dangerous and especially dangerous infections; study of genotypes of pathogens circulating in the territory of the Republic of Kazakhstan, as well as newly emerging infections of known and unknown etiology; study of the immune response to the impact of pathogens circulating in the territory of the Republic of Kazakhstan, as well as to newly emerging infections of known and unknown etiology; participation in monitoring studies as part of national and international programs for the study of dangerous and especially dangerous infectious diseases; development of control standard materials for genetic expertise; reference quality control of used and new means, materials and diagnostics.

JSC “Kazakh Scientific Research Veterinary Institute”:

– conducting epizootological monitoring, analysis of the obtained data, forecasting, assessment and management of the risks of the emergence and spread of especially dangerous, zoonotic and emerging infections in the territory of the Republic of Kazakhstan;

– development and improvement of means and methods for diagnostics, prevention of infectious and non-infectious diseases, treatment of sick livestock and technology for the production of drugs to protect animal health;

– development of methods for monitoring, assessing the quality and ensuring food safety of livestock and plant products;

– development and implementation of a system of anti-epizootic measures for the prevention and elimination of infectious and non-infectious animal diseases (national programs for the control of animal diseases in the Republic of Kazakhstan);

– scientific substantiation of regulatory documents on veterinary medicine, including those developed with the aim of obtaining the status of the territory of the Republic of Kazakhstan free from particularly dangerous infections (ensuring biosecurity of the Republic of Kazakhstan);

– determination of the quality of veterinary drugs, veterinary diagnostic studies, studies on compliance with the requirements of technical regulations of the Customs Union/Eurasian Economic Union according to the scope of accreditation (GOST ISO/IEC 17025);

– provider of proficiency testing in animal disease diagnostics according to the scope of accreditation for compliance with the requirements of GOST ISO/IEC 17043.

JSC “Republican Collection of Microorganisms:

– conducting scientific research on the storage and replenishment of collection cultures of industrially valuable microorganisms with the study of biological activity;

obtaining highly active cultures of microorganisms that are promising for various purposes in microbiology and biotechnology;

– conducting genetic and biochemical studies;

determination of in vitro antimicrobial activity of biopreparations of various etiologies and individual microorganisms; determination of sensitivity of microorganisms to a wide range of antibiotics and their MIC; determination of various types of biological activities; determination of FSP both of monocultures and as part of biopreparations; testing for purity of microorganisms;

– development of probiotics, study of molecular mechanisms of probiotics;

– development and technology of obtaining strains producing biopreparations for medicine, agriculture, and the food industry;

development of diagnostic test systems;

– development of multidisciplinary solutions and integrated technologies for the use of microorganisms and medicinal plants for the prevention and treatment of bacterial and parasitic infections.

JSC “Scientific and Analytical Center “Biomedpreparat”:

analytical studies: water quality analysis, determination of valuable metal content in iron ore, concentrates and agglomerates, general chemical analysis of soil/ground;
development and implementation of technologies for chemical and biological leaching of valuable metals from various types of ores;
creation of new drugs and innovative biotechnologies for agriculture and veterinary medicine;
development of biotechnological methods for the reclamation of various types of industrial and agricultural waste;
conducting scientific research in the field of plant biotechnology;

– participation in interlaboratory comparison tests.

State Enterprise on the Right of Economic Management “Research Institute for Biological Safety Problems”:

– development of veterinary drugs (vaccines);

– development of sanitizing drugs and bacteriophages for veterinary medicine and the food industry;

– preclinical studies of the efficacy and safety of antimicrobial drugs and vaccines against brucellosis;

– epizootological monitoring of particularly dangerous diseases of bacterial etiology;

– obtaining strains producing antigens of pathogens of bacterial infections in humans and animals;

– development of technology for the production of various finished forms of biological products; development and implementation of the technological process for the preparation of liquid (inactivated) and dry (lyophilized) biological products;

– diagnostics of viral and bacterial infections; development of new and improvement of existing means of laboratory diagnostics of viral and bacterial diseases of farm animals, birds and fur animals, as well as diagnostics of particularly dangerous infectious diseases;

– development of methods for indicating viruses of dangerous infectious diseases;

– study of the mechanisms of development of viral and bacterial infections using methods of virological, microbiological and molecular biological analysis;

– provision of the institute’s virology laboratories with cell cultures; creation of conditions for the development of work using cell cultures at a modern level; creation of a database on cell cultures; study of stem cells, their directed differentiation; study of cell biology in culture, creation of new cell lines; development of cell technologies for tissue replacement and cell therapy;

– deposit, preservation and maintenance in a biologically active state of strains of microorganisms of the collection and production bank of cell cultures; ensuring the preservation of strains of particularly dangerous pathogens and biological safety when working with them to prevent the accidental release of dangerous biological agents into the environment;

– development of new and improvement of existing technologies for cultivating microorganisms; selection and production of new, relevant vaccine strains and development of technologies for the production of preventive drugs based on them;

– conducting research on the adaptation of viruses to cell cultures; developing a method for cultivating viruses in cultures of transplantable cells grown on microcarriers; providing the institute’s scientific divisions with conditioned viral material for scientific research;

– development of technology for the production and use of vaccines against dangerous and especially dangerous diseases of animals, birds and humans; preclinical testing of the safety and immunogenicity of vaccines developed for healthcare and veterinary medicine in the Republic of Kazakhstan;

– production and release of vaccines against dangerous diseases of animals, birds, and humans;

– organization and implementation of technological and biological quality control of biological products for compliance with the requirements of GOST ISO/IEC 17025 “General requirements for the competence of testing and calibration laboratories” (accreditation certificate No. KZ.T.08.1389);

– maintaining a viable collection of phytopathogenic fungi of grain crops; studying the racial composition of the population of biotrophic and hemibiotrophic fungi that cause plant diseases;

– preservation and replenishment of the gene pool of grain crops of the Research Institute of Breeding and Biotechnology;

– conducting registration tests of pesticides (toxic chemicals);

– conducting genetic research: extraction of DNA, RNA from the material under study; identification of microorganisms by molecular genetic methods; development and synthesis of specific probes and primers; sequencing of DNA, cDNA using Sanger methods; full-genome (NGS) and partial determination of the nucleotide sequence of bacteria and viruses; genotyping of microorganisms, plants, animals; creation of genetic passports;

– breeding, raising and keeping animals for scientific research;

– implementation of veterinary-sanitary and zootechnical measures in order to ensure the epizootological well-being of laboratory animals in the department.

State Enterprise on the Right of Economic Management “Masgut Aikimbaev National Scientific Center for Particularly Dangerous Infections” of the Ministry of Health of the Republic of Kazakhstan:

– development and implementation of scientifically based methodological foundations for monitoring particularly dangerous infections and ensuring biological safety;

– ensuring the storage, regular replenishment, and maintenance of the viability of national and working collections of microorganisms for use in scientific purposes and the production of diagnostic drugs;

– development of new preventive and diagnostic drugs;

– production of SPF-category laboratory animals for scientific purposes.

OtarBioPharm LLP:

– production of pharmaceuticals;

– research and development in the field of anti-infective drugs;

– production and sale of medicinal products for veterinary medicine;

– scaling up the technology for producing biopreparations.

Scientific projects and scientific and technical programs

No.	IRN	Name of scientific projects and scientific and technical programs	Implementation period	Name of organization
1.	AP19676138	Prospects for using metagenomic analysis to monitor the circulation and spread of avian pathogens in Kazakhstan	2023-2025	JSC “Scientific Center for Anti-Infective Drugs”
2.	АР26194599	Comprehensive metagenomic analysis and resistome studies in swine epidemiology	2025-2027	JSC “Scientific Center for Anti-Infective Drugs”
3.	BR24992760	Development of a potentiator of the antimicrobial action of antibiotic combinations for the effective treatment of diseases caused by multidrug-resistant bacteria	2024-2026	JSC “Scientific Center for Anti-Infective Drugs”
4.	AP19576421	Genetic characteristics of some species of cestodes circulating in Kazakhstan	2023-2025	LLP “National Center of Biotechnology”
5.	AP19579275	Development of modern molecular diagnostics of agricultural crop pathogens based on the CRISPR/Cas12a method	2023-2025	LLP “National Center of Biotechnology”
6.	AP19579029	A molecular genetic study of the origins and progression of congenital spinal deformities in children in Kazakh families using whole-exome sequencing	2023-2025	LLP “National Center of Biotechnology”
7.	AP19574647	Development of modern biotechnologies for the conservation of biodiversity of endemic Tulipa sp. in Northern and Central Kazakhstan	2023-2025	LLP “National Center of Biotechnology”
8.	AP19676216	Evolutionary genomics of Mycobacterium tuberculosis in Kazakhstan: links between ancient and modern outbreaks	2023-2025	LLP “National Center of Biotechnology”
9.	AP19676555	Development and evaluation of an enzyme-linked immunosorbent assay based on a chimeric recombinant protein of the intracellular parasite Toxoplasma gondii	2023-2025	LLP “National Center of Biotechnology”
10.	AP19680500	Study of molecular mechanisms of mismatch repair in the tuberculosis pathogen Mycobacterium tuberculosis	2023-2025	LLP “National Center of Biotechnology”
11.	AP19678954	Study of collagenases for enzymatic hydrolysis of low-value waste from the meat processing industry into protein hydrolysates	2023-2025	LLP “National Center of Biotechnology”
12.	AP19678941	Study of biochemical parameters and coagulation activity of camel chymosin in mare's milk for the development of technology for deep processing of mare's milk	2023-2025	LLP “National Center of Biotechnology”
13.	AP19675359	Identification of patterns of production of biologically active metabolites with potential antioxidant and wound-healing activity in the culture of Rhodiola sp. stem cells	2023-2025	LLP “National Center of Biotechnology”
14.	AP19678901	Effective cellular immunotherapy in Kazakhstan: determining the optimal subpopulation composition of CAR+ cells for maximum activation, proliferation, and persistence	2023-2025	LLP “National Center of Biotechnology”
15.	AP19678106	Identification of new germline and somatic mutations in intracranial arteriovenous malformations	2023-2025	LLP “National Center of Biotechnology”
16.	AP19679502	Search for new donors and sources of genes for resistance to tomato Alternaria, and development of SCAR markers for the creation of resistant varieties	2023-2025	LLP “National Center of Biotechnology”
17.	AP19679015	Application of new data collection and processing methods based on machine learning algorithms for cellular proteome analysis	2023-2025	LLP “National Center of Biotechnology”
18.	AP19680504	Search and production of an efficient producer of environmentally friendly biodegradable plastic (polyhydroxybutyrate) from soil bacteria	2023-2025	LLP “National Center of Biotechnology”
19.	AP19674577	Determination of the possible protective effect of interleukin 15 in combination with anti-PD-L1 and anti-CTLA-4 antibodies on the immunity of cows with enzootic leukemia	2023-2025	LLP “National Center of Biotechnology”
20.	AP19679339	Production, study and modification of microbial PET hydrolases for biorecycling and conversion of plastic waste	2023-2025	LLP “National Center of Biotechnology”
21.	AP19679407	Development of agrobiotechnology for the introduction of the valuable medicinal and forage plant Rhapónticum carthamoídes in Northern Kazakhstan	2023-2025	LLP “National Center of Biotechnology”
22.	AP19680152	Molecular characterization of apple cytosporosis pathogens and identification of effective biocontrol agents for intensive horticulture in the Republic of Kazakhstan	2023-2025	LLP “National Center of Biotechnology”
23.	AP19679239	Proteogenetic analysis of enterotoxigenic strains of Bacteroides fragilis	2023-2025	LLP “National Center of Biotechnology”
24.	AP19678933	Genetic screening of newborns for immunodeficiency disorders in Kazakhstan: a pilot study	2023-2025	LLP “National Center of Biotechnology”
25.	AP22787291	Genetic characteristics of various types of fungal diseases infecting chickpeas in Kazakhstan	2024-2026	LLP “National Center of Biotechnology”
26.	AP22784368	Study of the distribution and species diversity of Babesia spp. in Kazakhstan and the development of PCR for the differential diagnosis of babesiosis	2024-2026	LLP “National Center of Biotechnology”
27.	AР23489638	Study of population and genetic diversity of the ocular microbiota of cattle with infectious keratoconjunctivitis	2024-2026	LLP “National Center of Biotechnology”
28.	AP23485562	Isolation, identification, characterization and application of pesticide-degrading bacteria with plant growth promoting potential for sustainable agriculture in Kazakhstan	2024-2026	LLP “National Center of Biotechnology”
29.	AP23489861	Development of in vitro biotechnology and cryopreservation of the endemic, endangered species Ledebour's almond (Amygdalus ledebouriana) for biodiversity conservation	2024-2026	LLP “National Center of Biotechnology”
30.	AP23487856	Study of the prevalence of coxiellosis in Kazakhstan and development of a domestic ELISA test system for its diagnosis	2024-2026	LLP “National Center of Biotechnology”
31.	АР23488977	Proteotranscriptomic analysis of colorectal cancer factors	2024-2026	LLP “National Center of Biotechnology”
32.	AP23488393	Study of the intracellular interactome of proteins of the viral replication complex	2024-2026	LLP “National Center of Biotechnology”
33.	AP23488467	Functional characteristics of Staphylococcus aureus DNA glycosylase	2024-2026	LLP “National Center of Biotechnology”
34.	АР23489692	Production of recombinant bacterial β-galactosidases for lactose hydrolysis and study of transglycosylation in the formation of galactooligosaccharides with prebiotic action	2024-2026	LLP “National Center of Biotechnology”
35.	AP23490126	Development and optimization of elements of the CRISPR/Cas9 system for studying the mechanisms of drought tolerance in potatoes	2024-2026	LLP “National Center of Biotechnology”
36.	AP23490103	Study of the therapeutic potential of adipose tissue pericytes in a model of diabetic retinopathy	2024-2026	LLP “National Center of Biotechnology”
37.	AP23488270	Study of sporogenesis of bacillary strains, editing of the genome of Bacillus licheniformis and Bacillus paralicheniformis bacteria and obtaining asporogenous producer strains	2024-2026	LLP “National Center of Biotechnology”
38.	AP23487935	Study and production of xylooligosaccharides by enzymatic hydrolysis of lignocellulosic raw materials for their use as nutraceuticals	2024-2026	LLP “National Center of Biotechnology”
39.	AP23488823	Isolation and characterization of a thermostable myoinositol phosphohydrolase of bacillary origin and production of a recombinant phytase for use in biotechnology	2024-2026	LLP “National Center of Biotechnology”
40.	АР23488541	Study of the distribution and species diversity of Theileria spp. and development of PCR for the differential diagnosis of theileriosis	2024-2026	LLP “National Center of Biotechnology”
41.	AP23487052	Avian infectious bronchitis in Kazakhstan: molecular genetic monitoring and development of a control strategy	2024-2026	LLP “National Center of Biotechnology”
42.	AP23483877	Study of the diagnostic value of immunodominant antigens of Babesia bigemina	2024-2026	LLP “National Center of Biotechnology”
43.	AP23489921	Development of a drought tolerance classification for the Kazakhstan cotton collection and identification of SNP markers associated with drought tolerance traits	2024-2026	LLP “National Center of Biotechnology”
44.	AP23486749	Phylogenetic analysis of the Y chromosome: from ancient to modern populations in Central Asia	2024-2026	LLP “National Center of Biotechnology”
45.	АР26102807	Study of wild and introduced populations of endangered species of Nedzvetsky apple and Sievers apple to select disease-resistant genotypes and create an in vitro collection for conservation	2025-2027	LLP “National Center of Biotechnology”
46.	АР26198457	Search and molecular genetic study of markers for resistance to false powdery mildew of sunflower (Plasmopara halstedii) using GBS and GWAS methods	2025-2027	LLP “National Center of Biotechnology”
47.	АР26103353	Development of a cell-based technology for the treatment of osteonecrosis of the femoral head based on 3D spheroids of mesenchymal stem cells	2025-2027	LLP “National Center of Biotechnology”
48.	АР26198829	Development of innovative hemostatic materials with prolonged release of coagulants	2025-2027	LLP “National Center of Biotechnology”
49.	АР26196975	Development of macroporous cell-filled polymers based on gelatin and hyaluronic acid	2025-2027	LLP “National Center of Biotechnology”
50.	АР26196601	Isolation and characterization of bacteriophages for use in poultry farming	2025-2027	LLP “National Center of Biotechnology”
51.	АР26104633	Study of genetic and morphological diversity of wild relatives and cultivated forms of Malus spp. in Kazakhstan to improve selection and species (varietal) identification	2025-2027	LLP “National Center of Biotechnology”
52.	АР26103427	Production of recombinant interferons type I (different subtypes) and comparison of antiviral activity against pathogens causing viral diseases of cattle	2025-2027	LLP “National Center of Biotechnology”
53.	АР26102073	Molecular genetic monitoring of retroviral infections of birds in Kazakhstan and development of approaches for their control	2025-2027	LLP “National Center of Biotechnology”
54.	АР27509399	Study of the effect of exosomes from preconditioned human umbilical cord mesenchymal stem cells in the treatment of atherosclerosis	2025-2027	LLP “National Center of Biotechnology”
55.	BR25293293	Implementation of CAR-T-based chimeric antigen receptor therapy for hematological tumors in practical healthcare	2024-2026	LLP “National Center of Biotechnology”
56.	BR24992881	Development of cellular, genomic and proteomic technologies for the diagnosis of socially significant diseases in the Republic of Kazakhstan	2024-2026	LLP “National Center of Biotechnology”
57.	BR28713087	Fundamental and applied aspects of obtaining and targeted synthesis of biologically active substances of medicinal plants in vitro culture	2025-2027	LLP “National Center of Biotechnology”
58.	AP19679355	Study of genes of resistance of plague and cholera pathogens to antibiotics, construction of a PCR test system	2023-2025	LLP “National Scientific Center for Particularly Dangerous Infections named after Masgut Aikimbaev”
59.	AP19680079	Study of molecular genetic characteristics and variability of plague and tularemia strains in epidemiological surveillance of zoonoses	2023-2025	LLP “National Scientific Center for Particularly Dangerous Infections named after Masgut Aikimbaev”
60.	AP23490794	Study of the prevalence of populations of pathogens causing salmonellosis and enterovirus infections with the development of diagnostic test systems based on PCR to improve epidemiological monitoring	2024-2026	LLP “National Scientific Center for Particularly Dangerous Infections named after Masgut Aikimbaev”
61.	BR25293296	Methodological foundations for the development and implementation of diagnostic drugs for particularly dangerous infections in order to ensure biological safety	2024-2026	LLP “National Scientific Center for Particularly Dangerous Infections named after Masgut Aikimbaev”
62.	BR24992948	Development of new diagnostic test systems for particularly dangerous viral infections	2024-2026	LLP “National Scientific Center for Particularly Dangerous Infections named after Masgut Aikimbaev”
63.	АР19676030	Identification of potential reservoirs of camelpox virus in Western Kazakhstan	2023-2025	LLP “Scientific Research Institute for Biological Safety Problems”
64.	АР19676490	Bluetongue: main carriers, distribution area and genetic characteristics of the virus circulating in Kazakhstan, and the introduction of a specific preventive measure	2023-2025	LLP “Scientific Research Institute for Biological Safety Problems”
65.	AP19676553	Epidemiological monitoring and development of modern diagnostic tools for particularly dangerous viral diseases of birds	2023-2025	LLP “Scientific Research Institute for Biological Safety Problems”
66.	AP19677632	Metagenomics of the microbiome of ixodid ticks in Kazakhstan	2023-2025	LLP “Scientific Research Institute for Biological Safety Problems”
67.	AP19678503	The role of viral immunomodulatory genes in the formation of the immune response to capripoxvirus vector vaccines	2023-2025	LLP “Scientific Research Institute for Biological Safety Problems”
68.	АР19678678	Prevalence and genetic diversity of flaviviruses in Kazakhstan	2023-2025	LLP “Scientific Research Institute for Biological Safety Problems”
69.	АР23485278	Search for lytic bacteriophages to create new therapeutic agents for the treatment of chicken salmonellosis	2024-2026	LLP “Scientific Research Institute for Biological Safety Problems”
70.	AP23488595	Crimean-Congo hemorrhagic fever: monitoring, study of molecular-genetic and biological parameters of the causative agent of the disease	2024-2026	LLP “Scientific Research Institute for Biological Safety Problems”
71.	АР23489672	A new phage-based biological drug to combat Treponema pallidum	2024-2026	LLP “Scientific Research Institute for Biological Safety Problems”
72.	AP23488477	Avian influenza vaccine based on mRNA technology	2024-2026	LLP “Scientific Research Institute for Biological Safety Problems”
73.	АР26198397	Development of an associated recombinant vaccine against lumpy skin disease and bluetongue in cattle	2025-2027	LLP “Scientific Research Institute for Biological Safety Problems”
74.	BR25293294	A genomic-based vaccine against brucellosis	2024-2026	LLP “Scientific Research Institute for Biological Safety Problems”
75.	BR22884615	Scientific support for the epizootic welfare of fish and livestock farms in the Republic of Kazakhstan for infectious and parasitic diseases	2024-2026	LLP “Scientific Research Institute for Biological Safety Problems”
76.	BR28712529	Development of means for specific prevention and diagnosis of monkeypox	2025-2027	LLP “Scientific Research Institute for Biological Safety Problems”
77.	AP19677697	Develop scientifically based measures for the prevention of gadfly and invasive diseases of camels and horses and ixodidosis in cattle	2023-2025	LLP “Kazakh Scientific Research Veterinary Institute”
78.	AP23489437	Production of recombinant proteins of Newcastle disease virus to create a universal vector	2024-2026	LLP “Kazakh Scientific Research Veterinary Institute”
79.	АР 26194327	Metagenomic study of the intestinal microbiome of marals and saigas in Kazakhstan: 16S rRNA sequencing and phylogenetic analysis	2025-2027	LLP “Kazakh Scientific Research Veterinary Institute”
80.	BR28712975	Scientific support for veterinary safety: development of new diagnostic tools and therapeutic and prophylactic drugs against infectious diseases of animals and birds	2025-2027	LLP “Kazakh Scientific Research Veterinary Institute”
81.	AP19678630	Production of a broad-spectrum biological fungicide to ensure and maintain high yields on farms in Kazakhstan	2023-2025	LLP “Republican Collection of Microorganisms”
82.	AP19679554	Development of integrated biotechnology for the use of probiotic microorganisms and medicinal plants	2023-2025	LLP “Republican Collection of Microorganisms”
83.	AP19679863	Production of a probiotic preparation for use in therapeutic and prophylactic purposes	2023-2025	LLP “Republican Collection of Microorganisms”
84.	AP19678528	Production of biopreparations that stimulate growth and protect planting material in forest park areas and horticultural farms in Kazakhstan	2023-2025	LLP “Republican Collection of Microorganisms”
85.	AP23483494	Technology for biorecycling of waste from wastewater treatment plants in the mangystau region for the production of biohumus	2024-2026	LLP “Republican Collection of Microorganisms”
86.	AP23483695	Development of biopreparations for accelerated fermentation of cattle waste	2024-2026	LLP “Republican Collection of Microorganisms”
87.	АР26102175	Development of a technology for biological treatment of wastewater from phosphorus-containing contaminants to improve the ecological state of the aquatic environment	2025-2027	LLP “Republican Collection of Microorganisms”
88.	BR218004/0223	Improving measures to ensure biological safety in Kazakhstan: countering dangerous and especially dangerous infections	2023-2025	JSC "National Holding QazBioPharm"