Directions of scientific activity of subsidiaries
JSC “Scientific Center for Anti-Infective Drugs”:
– development of new drugs with selective pharmacological action and biologically active substances, study of their physical and chemical properties and modeling of the structure of new substances and substances; study of the mechanisms of formation of bioactive substances and their stability;
– conducting scientific research at the intersection of related sciences (radiology, cytology, molecular biology), studying the mechanism of action and transport in a living organism of drugs labeled with radioactive isotopes;
– determination of the degree of humoral and cellular immune responses of animals and humans when exposed to medicinal substances in vivo and in vitro models;
– study of the antimicrobial efficacy of synthesized substances using CLSI and EUCAST methods, study of the mechanisms of action of drugs on bacterial cells, assessment of the potential mutagenic activity of new compounds within the framework of preclinical studies in accordance with the GLP standard;
– study of the mechanisms of formation of bacterial resistance to antibiotics and possible ways to overcome it, study of the mechanisms of genetically determined resistance of multiresistant strains that pose a threat to the biological safety of the Republic of Kazakhstan using next-generation sequencing, isolation, identification and determination of the sensitivity profile of clinical isolates isolated from healthcare facilities in Almaty, identification and characterization of pathogenicity and virulence factors;
– conducting studies of drug interactions (synergism, potentiation);
– scientific, methodological and analytical support of research based on international standards ISO, GLP and GMP, laboratory control of pilot production;
– development, research and implementation of methodological, methodological and technological foundations for the automation and intellectualization of complex modeling processes in biomedical research.
JSC “National Center for Biotechnology”:
– conducting molecular genetic studies: searching for genetic markers to predict and assess the risk of developing multifactorial diseases (oncological diseases, metabolic diseases, cerebrovascular diseases, etc.); pharmacogenetics; nutrigenetics; genomic studies; molecular genetic identification of various objects; development of PCR test systems for diagnosing infectious diseases in animals and humans; molecular genetic analysis of pathogens for the purpose of epidemiological monitoring; genogeographic studies of the gene pool; research in the field of paleogenetics; research in the field of forensic genetics; formation of a population genetic biobank of the Central Asian population;
– genetic engineering: molecular virology, study of viral replication mechanisms; creation of viral vectors for genetic modification of cells in vitro and ex vivo for gene therapy and CAR-T technology for the treatment of leukemia and lymphomas; production of recombinant antigens; fundamental research in the field of DNA repair of human bacterial pathogens ( Mycobacterium tuberculosis , Helicobacter pylori , Staphylococcus aureus ); functional characteristics of CRISPR/Cas systems for the development of affordable next-generation molecular diagnostics;
– proteomic studies: proteomic studies using mass spectrometry, systems biology (genome and proteome); search for new proteomic and epigenetic markers of oncological diseases and development of methods for their diagnosis; paleoproteomics;
– cellular and tissue engineering technologies: development of cellular and tissue engineering drugs for the treatment of wounds, articular cartilage defects and fractures; development of innovative methods and approaches to cellular therapy of autoimmune diseases using mesenchymal stem cells; development of “smart” and functionalized biomaterials, polymers for tissue engineering and regenerative medicine;
– research in the field of veterinary medicine: obtaining feed additives and probiotic preparations for use in agriculture;
– biotechnology and plant breeding: creation of new forms and varieties of plants; development of technologies for microclonal propagation of woody plants for landscaping; conservation and reproduction of endemic, rare, endangered and medicinal plant species using biotechnology methods; molecular genetic identification of plant varieties and forms, pathogens; creation of a gene bank and in vitro collection of rare and endangered plant species; molecular phytopathology; study and conservation of the biodiversity of plant genetic resources; development of technologies for obtaining plant stem cells for use as a source of biologically active substances;
– microbiology: isolation and study of microorganisms with biotechnological value; obtaining and studying enzymes, antigens, protein factors; targeted modification of enzymes, antigens, proteins; obtaining biotechnological products by microbial synthesis; isolation and replenishment of the collection of microorganisms with probiotic properties; isolation and replenishment of the collection of strains for the creation of biofertilizers, for bioremediation of anthropogenically disturbed soils of Kazakhstan; development of technology for fermentation, concentration, lyophilization of microorganisms;
– toxicology and pharmacology: bioscreening; toxicology; biomodeling; blood rheology pharmacology; transport systems; pharmacoeconomics;
– biological safety: prompt response to biological threats, including those caused by unknown pathogens, by means of metagenomic multisequencing and genetic analysis; implementation of reference functions in the field of sequencing and genomic analysis of pathogens of dangerous and especially dangerous infections; study of genotypes of pathogens circulating in the territory of the Republic of Kazakhstan, as well as newly emerging infections of known and unknown etiology; study of the immune response to the impact of pathogens circulating in the territory of the Republic of Kazakhstan, as well as to newly emerging infections of known and unknown etiology; participation in monitoring studies as part of national and international programs for the study of dangerous and especially dangerous infectious diseases; development of control standard materials for genetic expertise; reference quality control of used and new means, materials and diagnostics.
JSC “Kazakh Scientific Research Veterinary Institute”:
– conducting epizootological monitoring, analysis of the obtained data, forecasting, assessment and management of the risks of the emergence and spread of especially dangerous, zoonotic and emerging infections in the territory of the Republic of Kazakhstan;
– development and improvement of means and methods for diagnostics, prevention of infectious and non-infectious diseases, treatment of sick livestock and technology for the production of drugs to protect animal health;
– development of methods for monitoring, assessing the quality and ensuring food safety of livestock and plant products;
– development and implementation of a system of anti-epizootic measures for the prevention and elimination of infectious and non-infectious animal diseases (national programs for the control of animal diseases in the Republic of Kazakhstan);
– scientific substantiation of regulatory documents on veterinary medicine, including those developed with the aim of obtaining the status of the territory of the Republic of Kazakhstan free from particularly dangerous infections (ensuring biosecurity of the Republic of Kazakhstan);
– determination of the quality of veterinary drugs, veterinary diagnostic studies, studies on compliance with the requirements of technical regulations of the Customs Union/Eurasian Economic Union according to the scope of accreditation (GOST ISO/IEC 17025);
– provider of proficiency testing in animal disease diagnostics according to the scope of accreditation for compliance with the requirements of GOST ISO/IEC 17043.
JSC “Republican Collection of Microorganisms:
– conducting scientific research on the storage and replenishment of collection cultures of industrially valuable microorganisms with the study of biological activity;
- obtaining highly active cultures of microorganisms that are promising for various purposes in microbiology and biotechnology;
– conducting genetic and biochemical studies;
- determination of in vitro antimicrobial activity of biopreparations of various etiologies and individual microorganisms; determination of sensitivity of microorganisms to a wide range of antibiotics and their MIC; determination of various types of biological activities; determination of FSP both of monocultures and as part of biopreparations; testing for purity of microorganisms;
– development of probiotics, study of molecular mechanisms of probiotics;
– development and technology of obtaining strains producing biopreparations for medicine, agriculture, and the food industry;
- development of diagnostic test systems;
– development of multidisciplinary solutions and integrated technologies for the use of microorganisms and medicinal plants for the prevention and treatment of bacterial and parasitic infections.
JSC “Scientific and Analytical Center “Biomedpreparat”:
- analytical studies: water quality analysis, determination of valuable metal content in iron ore, concentrates and agglomerates, general chemical analysis of soil/ground;
- development and implementation of technologies for chemical and biological leaching of valuable metals from various types of ores;
- creation of new drugs and innovative biotechnologies for agriculture and veterinary medicine;
- development of biotechnological methods for the reclamation of various types of industrial and agricultural waste;
- conducting scientific research in the field of plant biotechnology;
– participation in interlaboratory comparison tests.
State Enterprise on the Right of Economic Management “Research Institute for Biological Safety Problems”:
– development of veterinary drugs (vaccines);
– development of sanitizing drugs and bacteriophages for veterinary medicine and the food industry;
– preclinical studies of the efficacy and safety of antimicrobial drugs and vaccines against brucellosis;
– epizootological monitoring of particularly dangerous diseases of bacterial etiology;
– obtaining strains producing antigens of pathogens of bacterial infections in humans and animals;
– development of technology for the production of various finished forms of biological products; development and implementation of the technological process for the preparation of liquid (inactivated) and dry (lyophilized) biological products;
– diagnostics of viral and bacterial infections; development of new and improvement of existing means of laboratory diagnostics of viral and bacterial diseases of farm animals, birds and fur animals, as well as diagnostics of particularly dangerous infectious diseases;
– development of methods for indicating viruses of dangerous infectious diseases;
– study of the mechanisms of development of viral and bacterial infections using methods of virological, microbiological and molecular biological analysis;
– provision of the institute’s virology laboratories with cell cultures; creation of conditions for the development of work using cell cultures at a modern level; creation of a database on cell cultures; study of stem cells, their directed differentiation; study of cell biology in culture, creation of new cell lines; development of cell technologies for tissue replacement and cell therapy;
– deposit, preservation and maintenance in a biologically active state of strains of microorganisms of the collection and production bank of cell cultures; ensuring the preservation of strains of particularly dangerous pathogens and biological safety when working with them to prevent the accidental release of dangerous biological agents into the environment;
– development of new and improvement of existing technologies for cultivating microorganisms; selection and production of new, relevant vaccine strains and development of technologies for the production of preventive drugs based on them;
– conducting research on the adaptation of viruses to cell cultures; developing a method for cultivating viruses in cultures of transplantable cells grown on microcarriers; providing the institute’s scientific divisions with conditioned viral material for scientific research;
– development of technology for the production and use of vaccines against dangerous and especially dangerous diseases of animals, birds and humans; preclinical testing of the safety and immunogenicity of vaccines developed for healthcare and veterinary medicine in the Republic of Kazakhstan;
– production and release of vaccines against dangerous diseases of animals, birds, and humans;
– organization and implementation of technological and biological quality control of biological products for compliance with the requirements of GOST ISO/IEC 17025 “General requirements for the competence of testing and calibration laboratories” (accreditation certificate No. KZ.T.08.1389);
– maintaining a viable collection of phytopathogenic fungi of grain crops; studying the racial composition of the population of biotrophic and hemibiotrophic fungi that cause plant diseases;
– preservation and replenishment of the gene pool of grain crops of the Research Institute of Breeding and Biotechnology;
– conducting registration tests of pesticides (toxic chemicals);
– conducting genetic research: extraction of DNA, RNA from the material under study; identification of microorganisms by molecular genetic methods; development and synthesis of specific probes and primers; sequencing of DNA, cDNA using Sanger methods; full-genome (NGS) and partial determination of the nucleotide sequence of bacteria and viruses; genotyping of microorganisms, plants, animals; creation of genetic passports;
– breeding, raising and keeping animals for scientific research;
– implementation of veterinary-sanitary and zootechnical measures in order to ensure the epizootological well-being of laboratory animals in the department.
State Enterprise on the Right of Economic Management “Masgut Aikimbaev National Scientific Center for Particularly Dangerous Infections” of the Ministry of Health of the Republic of Kazakhstan:
– development and implementation of scientifically based methodological foundations for monitoring particularly dangerous infections and ensuring biological safety;
– ensuring the storage, regular replenishment, and maintenance of the viability of national and working collections of microorganisms for use in scientific purposes and the production of diagnostic drugs;
– development of new preventive and diagnostic drugs;
– production of SPF-category laboratory animals for scientific purposes.
OtarBioPharm LLP:
– production of pharmaceuticals;
– research and development in the field of anti-infective drugs;
– production and sale of medicinal products for veterinary medicine;
– scaling up the technology for producing biopreparations.
Scientific projects and scientific and technical programs
| No. | IRN | Name | Implementation period | Abbreviation of the organization |
| 1 | BR09460548 | Development of new anti-infective drugs (NTP) | 2021-2023 | NCPP |
| 2 | BR09458960 | Study of reversal of antibiotic resistance in pathogenic microorganisms (NTP) | 2021-2023 | NCPP |
| 3 | AP09259374 | Modification of senolytic activity of antioxidants when included in milk exosomes in a model of human fibroblast aging | 2021-2023 | NCB |
| 4 | AP09260668 | Study of genetic diversity of the SARS-Cov-2 virus in Kazakhstan. | 2021-2023 | NCB |
| 5 | AP09260709 | Development of an ELISA test system for the diagnosis of coronavirus SARS-CoV-2 based on RBD and S protein | 2021-2023 | NCB |
| 6 | AP09258581 | Obtaining a hybridoma cell strain producing monoclonal antibodies against the extracellular fragment of the CTLA-4 receptor | 2021-2023 | NCB |
| 7 | AP09259771 | Characterization of new programmable RNA-guided endonucleases CRISPR/Cas systems for diagnostic applications | 2021-2023 | NCB |
| 8 | AP09259961 | Study of the therapeutic potential of cytokine-preconditioned human cord blood MSCs in rheumatoid arthritis | 2021-2023 | NCB |
| 9 | AP09260159 | Search among bio- and synthetic antioxidants for new biologically active substances capable of inhibiting the development of pulmonary fibrosis | 2021-2023 | NCB |
| 10 | AP09259357 | Development of an injectable hydrogel for effective regeneration of massive bone defects | 2021-2023 | NCB |
| 11 | AP09258813 | A Multiomics Approach to Studying the Cellular Response of Bacterioides fragilis to Carbapenems | 2021-2023 | NCB |
| 12 | AP09259560 | Study of genetic links between Kazakh and Kyrgyz clans, as well as with Altaians, Khakassians and Shors by means of phylogenetic analysis of Y-chromosome from Altai to Pamirs | 2021-2023 | NCB |
| 13 | AP09259964 | Study of the effect of p19 gene expression on the efficiency of site-directed mutagenesis to reduce the level of reducing sugars in potato using CRISPR/Cas9 | 2021-2023 | NCB |
| 14 | AP09259838 | Application of new proteomics methods to study the mechanism of action of pluripotency transcription factors expressed in mammalian cell lines | 2021-2023 | NCB |
| 15 | AR09259225 | Study of species diversity of Mycoplasmaspp associated with cattle infections of various etiologies | 2021-2023 | NCB |
| 16 | AR09260362 | Genetically engineered alfalfa plants (medicagoSativaL) for phytoremediation of soils contaminated with pesticides | 2021-2023 | NCB |
| 17 | AR09259527 | Historical, geneological and genetic research of the descendants of Genghis Khan | 2021-2023 | NCB |
| 18 | AP09058121 | Search for means of pharmacological correction of the syndrome of increased blood viscosity associated with endocrine pathology | 2021-2023 | NCB |
| 19 | AP09058045 | The influence of compensatory genetic factors on the development of drug-resistant tuberculosis in Kazakhstan | 2021-2023 | NCB |
| 20 | AP09058041 | Development of an immunochromatographic assay for the diagnosis of lumpy skin disease in cattle | 2021-2023 | NCB |
| 21 | AP09057948 | Studying the genetic basis of morbid obesity using whole exome sequencing | 2021-2023 | NCB |
| 22 | AP09058276 | A study of genetic variability in skin, hair and iris color in the Kazakh population | 2021-2023 | NCB |
| 23 | AP09058270 | Evaluation of biochemical activity of DNA repair enzymes of clinically important bacteria | 2021-2023 | NCB |
| 24 | AP09058538 | Historical and genetic study of Kazakh Shezhire | 2021-2023 | NCB |
| 25 | AR13068273 | Genome-wide characterization of genetic variation on the Drosophilamelanogaster X chromosome | 2022-2024 | NCB |
| 26 | AR13068136 | Development of alginate wound dressings with enhanced antibacterial and regenerative properties for the treatment of purulent wounds | 2022-2024 | NCB |
| 27 | AR13068269 | Study of the therapeutic effect of cytokine-preconditioned mesenchymal stem cell exosomes in a mouse model of psoriasis | 2022-2024 | NCB |
| 28 | AP14869645 | Establishing the genetic affiliation of various species of the echinococcosis pathogen to haplotypes circulating in the territory of Kazakhstan | 2022-2024 | NCB |
| 29 | AP14871433 | Development of new structural analogues of hypoglycemic drugs based on functional derivatives of 3-aminopyridones and evaluation of their antidiabetic activity | 2022-2024 | NCB |
| 30 | AP14872087 | Innovative research on viral diseases of millet ( PanicummiliaceumL .) to develop new strategies for improving productivity and resistance of varieties | 2022-2024 | NCB |
| 31 | AP14869820 | Fusobacteriumnucleatum and its role in the development of colorectal cancer | 2022-2024 | NCB |
| 32 | AP14869313 | Study of the distribution area and genetic diversity of Francisellatularensis subsp mediasiatica strains circulating in Kazakhstan | 2022-2024 | NCB |
| 33 | AP14869409 | Development of biotechnology of the red-listed species of currant Yanchevsky (Ribesjanczewskii) for conservation and reproduction | 2022-2024 | NCB |
| 34 | AP14870156 | Obtaining producers of monoclonal antibodies to cow PD-L1 and CTLA-4 receptors for the treatment of chronic viral and bacterial infections | 2022-2024 | NCB |
| 35 | AP14869708 | Isolation and study of new proteolytic enzymes of bacterial origin | 2022-2024 | NCB |
| 36 | AP14869821 | Development of a PCR test system for determining the species diversity of Anaplasma spp among cattle and small ruminants in Kazakhstan | 2022-2024 | NCB |
| 37 | AP14869969 | ELISA test system for diagnostics and determination of seroprevalence of cattle theileriosis in Kazakhstan | 2022-2024 | NCB |
| 38 | AP14870906 | Standardization and validation of an enzyme immunoassay test system based on a combination of periplasmic proteins BP26+SOD for serological monitoring of animal brucellosis | 2022-2024 | NCB |
| 39 | AP09259102 | Genetic characterization of bluetongue virus isolates detected in Kazakhstan and development of a domestic test system for their differential detection | 2021-2023 | Branch of the National Central Bank (Almaty) |
| 40 | AP09259103 | Identification of genomic and subgenomic characteristics of SARS-CoV-2 strains circulating in the Republic of Kazakhstan to develop evidence-based approaches to COVID-19 diagnostics | 2021-2023 | Branch of the National Central Bank (Almaty) |
| 41 | AP09259105 | Study of prevalence and genotypes of Coxiella burnetii in the southern region of Kazakhstan | 2021-2023 | Branch of the National Central Bank (Almaty) |
| 42 | AP14870683 | Prevalence and genetic characterization of relapsing fever pathogens (Relapsing Fever Borrelia) in the southern region of Kazakhstan | 2022-2024 | Branch of the National Central Bank (Almaty) |
| 43 | BR 10764899 | To study the epizootological characteristics of the country’s territory for particularly dangerous diseases and to develop veterinary and sanitary measures to increase their effectiveness (NTP) | 2021-2023 | KazNIVI |
| 44 | BR 10764975 | To develop and propose for production means and methods for diagnostics, disease prevention, therapy of infected animals and disinfection of soil anthrax foci (SAF) | 2021-2023 | KazNIVI |
| 45 | AR09260001 | Obtaining a biopreparation to ensure long-term storage and high quality of fruit crops in Kazakhstan | 2021-2023 | RCM |
| 46 | AP14869952 | Development of biopreparations to improve productivity and sustainability of young animals in poultry farming | 2022-2024 | RCM |
| 47 | BR18574066 | Creation of a biobank of biotechnologically significant industrial microorganisms for biosafety in the field of biotechnology, ecology, agriculture | 2023-2024 | RCM |
| 48 | O.001B | Biological safety of the Republic of Kazakhstan: assessment of threats, scientific and technical bases for their prevention and elimination | 2021-2023 | NIIBPB |
| 49 | AP09258770 | Development of technology for the production of inactivated vaccine against camel pox | 2021-2023 | NIIBPB |
| 50 | AP09259683 | Development of technology for the production of a vector vaccine for the prevention of bovine tuberculosis | 2021-2023 | NIIBPB |
| 51 | AP09058338 | Study of antiviral activity of drugs against the SARS-COV-2 virus in vitro and molecular epidemiological analysis of circulating COVID-19 strains | 2021-2023 | NIIBPB |
| 52 | AP14870987 | Identification and preservation of wheat varieties with mechanisms of tolerance to major fungal diseases | 2022-2024 | NIIBPB |
| 53 | AP13067641 | Monitoring the spread of coronavirus among domestic animal species and studying the biophysical and physicochemical properties of coronavirus isolates isolated in the Republic of Kazakhstan | 2022-2024 | NIIBPB |
| 54 | BR11065207 | Development and scientific substantiation of public health technologies, biological safety for impact on prevention of dangerous infectious diseases | 2021-2023 | NNTSOOI |
| 55 | AR09261078 | Study of genetic diversity of plague strains to create a biorepository and determine the genesis of plague enzootic nuclei in natural foci of Kazakhstan | 2021-2023 | NNTSOOI |
| 56 | AR09259865 | Study of the early immune response to COVID-19 in a Syrian hamster model under chronic inflammation and the preventive activity of metformin | 2021-2023 | NNTSOOI |